Major histocompatibility complex class II (MHCII) bound to a peptide antigen mediates interactions between CD4+ T cells and antigen-presenting cells. Targeting peptide–MHCII with T cell antigen receptors (TCRs) and TCR-like antibodies has shown promise for autoimmune diseases and microbiome tolerance.
T cells and antigen-presenting cells. Targeting peptide–MHCII with T cell antigen receptors and TCR-like antibodies has shown promise for autoimmune diseases and microbiome tolerance. To develop a general targeting approach, we introduce targeted recognition of antigen–MHC complex reporter for MHCII for the rapid development of peptide-specific MHCII binders.
We thank A. Muselman and E. Engleman for help and support on animal experiments. We thank C. A. Choe for helpful discussion and N. Roan for helpful comments and feedback on the paper. We thank the National Institutes of Health Tetramer Core Facility for providing all HLA-DR tetramer reagents. We thank R. Yan at the Janelia Cryo-EM facility and E. Montabana at the Stanford University Cryo-Electron Microscopy Center for help in microscope operation and data collection. H.D.
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