While targeted intervention improved hyponatremia in hospitalized patients, subsequent benefits in mortality and rehospitalization were not observed.
SAN DIEGO — The use of a targeted plasma sodium correction did not reduce 30-day mortality and rehospitalization rates in hospitalized patients with hyponatremia despite often achieving normonatremia, results of a large, prospective, randomized study showed.
However, data are lacking on how — or even if — proper treatment of hyponatremia can prevent those disorders, said Refardt, who presented the results here at theTo investigate, she and her colleagues conducted the randomized, international, multicenter Hyponatremia Intervention Trial , enrolling 2174 hospitalized patients at nine centers across Europe with hyponatremia, defined for the study as serum sodium concentrations < 130 mmol/L.
Patients were excluded if they had severe symptomatic hyponatremia in need of hypertonic saline or if they had end-stage kidney disease or active liver failure or were receiving end-of-life care.
Hyponatraemia Renal Disease Kidney Disease Kidney Disorder Renal Disorder Nephropathy Clinical Guidelines Guidelines Europe European Hospitals Kidneys Plasma Liver Failure Hepatic Failure Clinical Research Clinical Trials Clinical Studies Pre-Clinical Trial Double-Blind Study Double-Blind Studies Single-Blind Study Single-Blind Studies Demyelination Demyelinating
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