A new study proposes a better understanding of the site of inflammation in RA which will allow for the development of new treatment strategies or predictive biomarkers which could support the potential for a 'personalized medicine' approach.
Research findings offer a unique opportunity for early diagnosis and therapeutic intervention for rheumatoid arthritisA new study proposes a better understanding of the site of inflammation in RA which will allow for the development of new treatment strategies or predictive biomarkers which could support the potential for a 'personalized medicine' approach.
The team identified that these cells are resident in the joint which, in health play a protective role, but in disease -- for reasons we are unsure of -- become pro-inflammatory, and release proteins called cytokines that induce inflammation, and also have the ability to activate the invasive fibroblast cell type which leads to cartilage and bone destruction.
Found this macrophage subtype is highly pro-inflammatory and releases proteins called cytokines that cause further inflammation in the joint. Importantly, the identification of a dominant macrophage subtype suggests targeting of CD40 signalling could represent a new strategy for patients who currently don't respond to treatment.
Joint Pain Diseases And Conditions Immune System Joint Health Medical Topics Cancer Wounds And Healing
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