Compounds containing astatine-211 (211At) can be used in targeted radiotherapies for prostate cancer, but deastatination in the body remains a significant hurdle. Now, researchers have developed a new molecule with a neopentyl glycol structure that effectively prevents deastatination.
Compounds containing astatine-211 can be used in targeted radiotherapies for prostate cancer , but deastatination in the body remains a significant hurdle. Now, researchers have developed a new molecule with a neopentyl glycol structure that effectively prevents deastatination. The proposed structure can be leveraged to accumulate harmful 211At only in tumors while minimizing damage to healthy tissues, paving the way to effective prostate cancer treatment.
A clever strategy for fighting mCRPC is to exploit the fact that these tumor cells usually overexpress a membrane protein called prostate-specific membrane antigen . In particular, targeted alpha therapy involves attaching a radioactive atom like actinium-225 to a compound that binds strongly to PSMA. As the radioactive atom decays, it emits alpha particles that are harmful to nearby cells -- in this case, tumor cells.
Taken together, the results of these in vivo experiments highlight the potential of NpG-D-PSMA for targeted alpha therapy."Our study showed that the neopentyl glycol structure, which can stably hold radiohalogens likeI in vivo, may be applicable as a tumor-targeting agent.
Researchers have made an important discovery about how prostate cancer may start to develop. A new study reveals that the prostate as a whole, including cells that appear normal, is different in men ...
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