A diverse, real-world patient population with triple-negative breast cancer that received pembrolizumab showed similar overall rates of immune-related adverse events.
developed immune-related adverse events — findings that are comparable, overall, to those from the landmark KEYNOTE-522 trial. However, there were some differences, including higher rates of gastrointestinal immune-related adverse events, some of which were “severe enough” that pembrolizumab was discontinued.
A toxicity was considered an immune-related adverse event if it met one of the following: Pathologic confirmation by biopsy, clinical improvement after treatment for the adverse event, or a documented diagnosis by a physician.Overall, 80 patients developed a distinct immune-related adverse event , and 18 of these patients experienced more than one immune-related adverse event.
Malignant Breast Neoplasm Breast Carcinoma Toxicology Toxicity Poisoning Toxins Cancer Malignant Neoplasia Carcinoma Malignant Neoplasm Triple Negative Breast Cancer Triple-Negative Breast Cancer Hypothyroidism Breast Mammary Gland Texas Thyroid Disorder Thyroid Disease Thyroid Dysfunction Chemotherapy Colitis Taxanes
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