Researchers tracked the health of nearly one thousand mice on a variety of diets to see if these diets would extend the mice's lifespan. The study was designed to ensure that each mouse was genetically distinct, which allowed the team to better represent the genetic diversity of the human population.
Researchers tracked the health of nearly one thousand mice on a variety of diets to see if these diets would extend the mice's lifespan. The study was designed to ensure that each mouse was genetically distinct, which allowed the team to better represent the genetic diversity of the human population. By doing so, the results are made more clinically relevant, elevating the study to one of the most significant investigations into aging and lifespan to date.
The study concluded that eating fewer calories had a greater impact on lifespan than periodic fasting, revealing that very-low-calorie diets generally extended the mice's lifespan regardless of their body fat or glucose levels -- both typically seen as markers of metabolic health and aging. Surprisingly, the mice that lived the longest on the restrictive diets were those that lost the least weight despite eating less.
Overall, mice on unrestricted diets lived for an average of 25 months, those on the intermittent fasting diets lived for an average of 28 months, those eating 80% of baseline lived for an average of 30 months, and those eating 60% of baseline lived for 34 months. But within each group, the range of lifespans was wide; mice eating the fewest calories, for example, had lifespans ranging from a few months to four and a half years.
The study also cast doubt on traditional ideas about why certain diets can extend life in the first place. For example, factors like weight, body fat percentages, blood glucose levels and body temperature did not explain the link between cutting calories and living a longer life. Instead, the study found that immune system health and traits related to red blood cells were more clearly connected to lifespan.
Obesity Healthy Aging Fitness Mice Food Biotechnology And Bioengineering Genetically Modified
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