While IL-17 blocking agents are linked to an increased risk for candidiasis, bimekizumab, which blocks two proteins simultaneously, may increase it even further, thanks to a previously unknown synergistic effect on neutrophils.
Drugs that simultaneously block interleukin -17A and IL-17F reduced the movement of protective white blood cells, making it harder for them to clear fungal infections and resulting in a higher risk for mucosal and systemicBlood was drawn from 10 patients with psoriatic arthritis and centrifuged to isolate neutrophils.
Chemotaxis assays were performed to measure neutrophil migration based on their optical density in the presence of different combinations of the cytokines IL-17A and IL-17F and anti-IL-17A and anti-IL-17F monoclonal antibodies.
Group for Research and Assessment of Psoriasis and Psoriatic Arthritis 2025 Annual Meeting and Trainee Symposium in Bogotá, Colombia. “We thought it might be because of the neutrophil chemotaxis, and the results exactly translated to that. However, bimekizumab also has very good efficacy in PsA . So we need to balance efficacy with increased monitoring of patients.
Candidiasis Thrush Yeast Infection Neutrophils Psoriatic Arthritis Arthropathic Psoriasis Psoriatic Arthropathy Psa Psoriatic Arthritis (Psa) Biologic Therapy Biologics Arthritis Joint Inflammation Candida Cytokines Monoclonal Antibody Cetuximab Rituximab Blood Psoriasis California Clinical Research Clinical Trials Clinical Studies Pre-Clinical Trial
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