People who work the nightshift or odd hours and eat at irregular times are more prone to weight gain and diabetes, likely due to eating patterns not timed with natural daylight and when people typically eat.
But is it possible to stave off the ill effects of eating at these 'unusual' times despite it not being biologically preferable? A study says 'yes', and sheds light on how the body knows when to eat. The study explains how researchers discovered a connection between the liver's internal clock and feeding centers in the brain.
The team's research showed that the liver sends signals to the brain via the vagus nerve, letting the brain know if eating is happening at a time that follows the body's circadian rhythm. These signals can get disrupted from working unusual hours. The brain then overcompensates, leading to overeating at the wrong times.
The effects were reversible. Cutting the nerve connection in obese mice restored normal eating patterns and reduced food intake."This suggests that targeting this liver-brain communication pathway could be a promising approach for weight management in individuals with disrupted circadian rhythms," said Lauren N. Woodie, PhD, a post-doctoral researcher in Lazar's lab.
The study was funded by the National Institutes of Diabetes, Digestive Diseases, and Metabolism, the JPB Foundation, and the Cox Medical Research Institute.Lauren N. Woodie, Lily C. Melink, Mohit Midha, Alan M. de Araújo, Caroline E. Geisler, Ahren J. Alberto, Brianna M. Krusen, Delaine M. Zundell, Guillaume de Lartigue, Matthew R. Hayes, Mitchell A. Lazar.To keep weight in check, it is not only important to consider what we eat, but also the times at which we eat.
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