Treatments for eye diseases are considered among the most promising for stem cells, which have been under study for more than 3 decades. While proponents say all this groundwork is finally coming to fruition, others call progress slow and plodding. More:
"We are still far away from the hundreds of diseases that could be eradicated with stem cells," says James Wells, PhD, the chief scientific officer at the Center for Stem Cell and Organoid Medicine at Cincinnati Children's Hospital."Most of the trials are only dealing with 'Are they safe?''' he says, referring to the first phase of clinical trials that is used only to see if a treatment is safe, not how well it works.
In comparison, Wells says, prescription drugs often take 15 years to progress from research stages to market.On its ''clinical dashboard" page, CIRM, California's stem cell agency, lists 56 clinical trials it has funded. CIRM, formerly the California Institute for Regenerative Medicine, was launched after California voters approved Proposition 71 in 2004, providing $3 billion for stem cell research.
Researchers first obtain blood-forming stem cells from a patient's bone marrow, deliver a normal gene to the cell, then infuse the stem cells back into the patient. The genetically corrected system cells settle in and start producing new blood cells.Macular degeneration: The research is now in phase 3, with an estimated enrollment of 75. Researchers want to show that the approach is safe and effective, and see if it ends the need for the immunosuppressive drugs. The study is due to be completed in January 2022.Other researchers are working on using embryonic stem cell therapy to treat type 1 diabetes, which happens when the immune system destroys the beta cells in the pancreas that make insulin.
These approaches won't just potentially find and evaluate new drugs, he says, but find a drug that treats a person’s disease, taking into account different forms of disorders.Controversy about the source of stem cells for research is ongoing. In early June, the U.S.
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