A complex molecular machine, the spliceosome, ensures that the genetic information from the genome, after being transcribed into mRNA precursors, is correctly assembled into mature mRNA. Splicing is a basic requirement for producing proteins that fulfill an organism's vital functions.
Structural biologists provide a first-time look at the atomic level into the quality control mechanism of this complex molecular machineA complex molecular machine, the spliceosome, ensures that the genetic information from the genome, after being transcribed into mRNA precursors, is correctly assembled into mature mRNA. Splicing is a basic requirement for producing proteins that fulfill an organism's vital functions.
The genetic information of all living organisms is contained in the DNA, with the majority of genes in higher organisms being structured in a mosaic-like manner. So the cells are able to"read" the instructions for building proteins stored in these genetic mosaic particles, they are first copied into precursors of mRNA, or. The spliceosome then converts them into mature, functional mRNA.
The research was carried out as part of a long-term collaboration between the teams of Prof. Sinning and Prof. Dr Tamas Fischer, who specializes in RNA surveillance at the Australian National University in Canberra. Prof. Dr Henning Urlaub's research group at the Max Planck Institute for Multidisciplinary Sciences in Göttingen also participated. The work was funded by the German Research Foundation and the Australian Research Council.
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