Social Connections Mitigate Genetic Risk for Depression

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Social Connections Mitigate Genetic Risk for Depression
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Social connections strongly protected against repeated depressive episodes.

, sedentary behavior, and social connections. For each lifestyle facet, behaviors were coded as healthy or unhealthy. For example, never smoking, engaging in regular exercise, consuming moderate amounts of alcohol, eating a healthy diet, getting 7-9 hours of sleep per night, and sitting at a computer or watching a screen for 0-4 hours per day were considered “healthy.

Depression diagnoses, brain imaging, and genetic information were obtained through medical records with the participants’ consent. The average age of respondents was 57 years old and 50.7% of respondents identified as female. Of the 287,282 participants, 12,916 were diagnosed with a depressive event at least once during the nine-year period of the study.The researchers found that each of the seven lifestyle factors independently reduced the risk for depression.

. Although participants with low genetic risk and more favorable lifestyles showed the greatest decreases in depression diagnoses, those “participants with high genetic risk but favorable lifestyle had a lower risk of depression than those with intermediate or low genetic risk but unfavorable lifestyle.”

The brain imaging results indicated that a healthier lifestyle was associated with larger brain volume “in cortical structures such as the superior prefrontal cortex, orbitofrontal cortex, precentral cortex and insula, and subcortical structures including the pallidum, thalamus, amygdala, and hippocampus…which might suggest improved cognitive control andThe authors noted that in the current study lifestyle factors were assessed via self-report, rather than more objective measurements such as...

groups and that the participants involved in the study tended to be healthier than the general population.The authors concluded that “favorable lifestyle plays a strongly protective role in the prevention of depression across a population with different polygenetic risk.” Furthermore, the authors noted that a healthy lifestyle encourages both physical and neurological health.

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