Drs Michael Kornberg and Pavan Bhargava discuss the effects of smoldering inflammation in disease progression and potential new therapies.
Associate Professor, Staff Physician, Department of Neurology, Johns Hopkins Hospital, Baltimore, Maryland Assistant Professor, Department of Neurology, Johns Hopkins University; Attending Neurologist, Department of Neurology, Division of Neuroimmunology and Neurological Infections, Johns Hopkins Hospital, Baltimore, Maryland
These can be identified either as by the presence of a paramagnetic rim, which is a rim of the iron-laden macrophages around the lesion, or on a kind of imaging called susceptibility-weighted imaging, which can be sensitive to the presence of iron, or as slowly expanding lesions, which are lesions that are gradually increasing in size over time.
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