Researchers have identified significant and specific variations in the microbial universe of the small intestine in overweight or obese adults compared with normal-weight peers.
Imbalance s in microbial populations have previously been observed in stool samples of patients with obesity-related diseases. This is the first study to fully examine the small bowel microbiome in different weight categories.
Duodenal aspirates and serum samples were obtained from 214 adults undergoing routine esophagogastroduodenoscopy without colon preparation.IN PRACTICE: "We identify small bowel microbial species associated with overweight and obesity, as well as escalation and de-escalation features that could potentially be selected as therapeutic targets. These findings illustrate that, although stool studies can and have provided very valuable data, direct analysis of the small bowel has yielded specific targets for further study," the authors wrote.The study, with first author Gabriela Leite, PhD, with the Medically Associated Science and Technology program, Cedars-Sinai, Los Angeles, wasThe population was heterogeneous, with different indications for upper endoscopy, and the diet was not standardized. Samples were obtained at a single timepoint, and cause-and-effect relationships cannot be established.This research was partially funded by the Monica Lester Charitable Trust and the Elias Genevieve and Georgianna Atol Charitable Trust. The authors have declared no conflicts of interest related to this study.All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC. This website also contains material copyrighted by 3rd parties.
Obese Duodenal Dyslipidemia Dyslipidaemia Metabolism Metabolic Small Intestinal Microbiome Microbiota Biomarker Biological Marker Multi-Biomarker Disease Activity MBDA Multibiomarker Disease Activity Blood Diet Endoscopy Escherichia Coli Escherichia Coli Infection E. Coli E. Coli Infection Esophagogastroduodenoscopy Imbalance Lipids Lipid Management
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