The severity of TRD appeared to predict response to IV ketamine vs ECT. However, experts said more research is needed before drawing any definitive conclusions.
Investigators found patients with moderate TRD had greater symptom improvement following ketamine treatment, while those with more severe TRD had better outcomes with ECT.
Investigators conducted a secondary analysis of data from ELEKT-D trial, a multicenter, open-label randomized trial of ECT and IV ketamine for TRD. The new analysis was designed to identify factors that could be used to flag which patients would benefit most from ECT and which ones might have better outcomes with ketamine.Participants with moderate depression had better outcomes with ketamine, a difference that was evident after only a few treatments, said Jha. Those with more severe TRD experienced greater improvement with ECT.
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