A SELECT trial subanalysis showed that semaglutide works as well in people with CVD, overweight/obesity, and impaired kidney function as it does in those with normal kidney function.
Participants with impaired kidney function treated with semaglutide showed a 31% reduction in major adverse cardiovascular events and a 33% lower risk of MACE or death from any cause.
SELECT enrolled 17,604 adults with a body mass index of 27 kg/m² or higher and a history of CVD across 41 countries. Participants received once-weekly semaglutide or placebo . Median follow-up was 3.5 years.ratio of 30 to < 300 mg/g, and 11% taking placebo had a UACR of 30 to < 300 mg/g.) comprised the primary endpoint, and the treatment effect on combined MACE and death from any cause was also an endpoint.
In addition, semaglutide was associated with a 20% reduction in MACE in both those with normal albumin or with albuminuria at baseline, she reported. Commenting on the work, comoderator, Fiona Gribble, MBChB, DPhil, professor of endocrine physiology, University of Cambridge, UK, said:"I think the results showed very convincingly that semaglutide works very effectively in people with impaired kidney function as without."
Chronic Kidney Failure CKD - Chronic Kidney Disease Chronic Kidney Disease CKD CV Risk Cardiovascular Risk CV Risk Factors Cardiovascular Risk Factors Cardiovascular Risk Management Kidneys Body Mass Index BMI UK Site Content United Kingdom Site Content United Kingdom UK Europe European Cardiovascular Disease Cvd - Cardiovascular Disease Myocardial Infarction
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