Science, Space and Technology News 2024
Semaglutide, an anti-obesity drug, may significantly reduce heart attacks and deaths in overweight individuals with cardiovascular disease, including those with heart failure, according to a study from the SELECT trial. Further research is needed to confirm its benefits for heart failure patients.
They found that semaglutide was linked to a 28% reduction in major adverse cardiac events , as well as a 24% reduction in cardiovascular disease-related deaths for this subgroup of people with pre-existing heart failure, and a 19% reduction in deaths of any cause. The study looked at data from the landmark SELECT trial – the largest and longest clinical trial of the effects of semaglutide on weight in over 17,000 adults who did not have diabetes but who were overweight or obese. The international team that runs the trial includes Professor Deanfield.Semaglutide, a GLP-1 receptor agonist, simulates the functions of the body’s natural incretin hormones, which help to lower blood sugar levels after a meal.
The researchers said the reduction in all-cause mortality in all heart failure groups “suggests the potential for other, as yet unknown, benefits.” These findings, they said, supported the use of semaglutide, on top of usual care, to reduce the risk of major adverse cardiac events in a broad population of people with established atherosclerotic cardiovascular disease and overweight/obesity.
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