Canadian researchers at the University of Montreal have successfully recreated and mathematically confirmed two molecular languages at the origin of life. Their groundbreaking findings, recently published in the Journal of American Chemical Society, pave the way for advancements in nanotechnologi
The illustration depicts two chemical languages at the basis of molecular communication. The same white molecule, represented as a lock, is activated either via allostery or multivalency . The allosteric activator induces a conformational change of the lock while the multivalent activator provides the missing part of the lock, both enabling the activation by the key .
In yeasts, for example, upon detecting and binding a mating pheromone, billions of molecules will communicate and coordinate their activities to initiate union, said Vallée-Bélisle, holder of a Canada Research Chair in Bioengineering and Bionanotechnology. Researchers Alexis Vallée-Bélisle and Dominic Lauzon in the process of designing chemical languages using a DNA synthesizer. Credit: Amélie Philibert | Université De Montréal
-based molecular system that could function using both languages. “DNA is like Lego bricks for nanoengineers,” said Lauzon. “It’s a remarkable molecule that offers simple, programmable, and easy-to-use chemistry.”The researchers found that simple mathematical equations could well describe both languages, which unraveled the parameters and design rules to program the communication between molecules within a nanosystem.
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