Researchers at Weill Cornell Medicine have illuminated one of the important ways that cells respond to stress. The findings could also be relevant to Alzheimer's, ALS and other diseases in which this mechanism may be abnormally active.
A an mRNA has, the more YTHDF proteins are present. The large amount of YTHDF proteins is needed to allow the m6
A wasn't the only factor directing mRNA into stress granules because longer mRNAs are also overrepresented."We had thought that mRNA length was another factor, which is plausible since longer mRNAs have a tendency to stick to other mRNAs and form aggregates," Dr. Jaffrey said.A and induced stress granule formation, they found that longer mRNAs weren't overrepresented in the granules anymore. Dr.
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