Scientists at Nanyang Technological University, Singapore (NTU Singapore) have found how human cells distribute and maintain their cholesterol levels, contributing to research into neurodegenerative diseases such as Alzheimer's disease as well as cardiovascular diseases. The findings were published in the journal Nature Communications.
Models of the regulation of non-vesicular cholesterol transport at ER-TGN contacts. Models of the regulation of non-vesicular cholesterol transport at ER-TGN contacts. ORP9 and OSBP are recruited to the ER via interaction of their FFAT motif with the MSP domain of VAPs. GRAMD1s are anchored to the ER via their transmembrane domain. ORP9 is recruited to the TGN via interaction with ORP10 and ORP11, which is mediated by its tandem α-helices.
"The study is of particular significance as disruptions in this process have been strongly associated with a wide range of neurodegenerative disorders, including Alzheimer's disease." Saheki is also a cell biologist and a medical doctor. functions and becomes susceptible to diseases, reflects NTU's commitment to responding to the needs and challenges of healthy living and aging, which is one of four humanity's grand challenges that the University seeks to address through its NTU 2025 strategic plan.Through using a cholesterol biosensor to measure levels of cholesterol, the researchers found that the proteins called ORP9 and OSBP regulate the distribution and abundance of cholesterol within the cell.
"A healthy and low amount of cholesterol keeps them flexible and fluid, while a higher cholesterol level makes them stiff. When dysregulation of cholesterol takes place in brain cells, it has been linked to diseases such as Alzheimer'sDr. Naito added,"We are working hard to determine how the cholesterol regulators we identified in this study affect human health.
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