Science, Space and Technology News 2023
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The clock revealed that diseases such as diabetic retinopathy and uveitis cause accelerated aging within specific cell types. Surprisingly, the researchers also detected proteins associated with Parkinson’s disease within eye fluid, which they say could offer a pathway to earlier Parkinson’s diagnoses.“What’s amazing about the eye is we can look inside and see diseases happening in real-time,” says senior author Vinit Mahajan, a surgeon and professor of ophthalmology at Stanford University.
Though liquid biopsies can provide a snapshot of what proteins are present in the region of interest, they have thus far been limited in their ability to measure large numbers of proteins within the small volumes of fluid, and they are also unable to provide information on which cells produced which proteins, which is important for diagnosing and treating diseases.
The researchers also detected several proteins that are associated with Parkinson’s disease. These proteins are usually identified postmortem and current diagnostic methods aren’t capable of testing for them, which is one reason Parkinson’s diagnoses are so difficult. Screening for these markers in eye fluid could enable earlier diagnosis of Parkinson’s disease and later therapeutic monitoring.
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