The discovery could introduce new ways of preventing some of the most severe allergic reactions.
Some bacteria common to the human digestive system appear to be great at neutralizing an allergic response to peanuts , which are not nuts but legumes.A host of tiny microbes common to both human mouth and gut microbiomes have been shown to capably diffuse several hazardous proteins known to trigger peanut allergies.
In other words, some of our very own saliva and stomach juices may already contain the microbes needed to break down some of the most dangerous allergens associated with peanuts. Among the microbes studied, a bacterium of the genusASV 14171, proved to be the most effective at reducing allergic responses and may lead to new medical treatments in the future. “Peanut allergies can cause serious reactions like difficulty breathing, and in some cases, can even be life threatening,” according to Liam Rondeau, a postdoctoral fellow with McMaster University’s Farncombe Family Digestive Health Research Institute in Ontario, which led the multicenter study. “However, some people with peanut allergies can still eat small amounts without having a reaction,” Rondeau noted in a statement. “We were curious about why.”. The condition is also among the most likely food allergies to lead to unintended exposures and severe episodes—with somewhere between seven and 14% of all people who are allergic to peanuts experiencing a reaction annually. Anywhere from one-third to one-half of those unwanted annual episodes include anaphylaxis: a potentially fatal immune system response marked by skin rashes, nausea, steep drops in blood pressure, and a suffocating narrowing of the breathing pathway. Adding to these dangers, peanut allergies are much more likely than other food allergies to endure onward into adulthood, extending these risks for Two proteins present in peanuts, labelled Ara h 1 and 2, have long been determined to be the dominant allergenic compounds responsible for these overwrought and dangerous immune system freak-outs. And, to test which common digestive bacteria worked best to neutralize these proteins, the researchers turned to specialized lab mice with peanut allergies, as well as to carefully segregated petri dishes of individual bacteria from human mouths and small intestines.Given how quickly a peanut allergy can take hold, the team focused on the bacteria present in human saliva for theiror Petri dish, trials, examining bacterial samples from 13 hardy volunteers with no reported food allergies. While bacteria capable of degrading the Ara h 1 and 2 proteins were detected and isolated for a variety of genera, including, a dominant genus in the oral microbiome, proved effective against both Ara h 1 and Ara h 2. One species in particular—study that had logged the prevalence of various bacteria within the oral microbiome, the gut microbiome, and elsewhere inside the bodies of 120 children with suspected peanut allergies. This cohort included 23 ultimately non-allergic control patients, 74 allergic patients with a high threshold for peanut exposure , and 23 with a low threshold for peanut exposure .was “significantly more abundant” in the saliva of those with no allergic response or a high tolerance to peanut exposure. “Microbes in the mouth and gut play an important role in digestion,” said the study’s co-senior author, Alberto Caminero Fernandez, a gastroenterologist and an associate professor with McMaster’s Department of Medicine. “These findings point to a newly identified pathway linking the oral and gut microbiome with food allergy,” he added in aThose treatments, according to the university, may involve new probiotic therapies with cultured bacteria possibly supplementing traditional oral immunotherapy strategies, in which patients are gradually introduced to larger and larger amounts of the allergen as their body learns to adapt. McMaster University and their partners in Spain and the United States published their results online this Tuesday in the journal6:30 amSame Poop, Different Results: At-Home Gut Health Tests Are Wildly Inconsistent, Study Finds New research has found that different gut health testing companies can provide wildly different results from the same fecal sample.This Pocket-Sized Lab Might Prevent You From Going Into Anaphylactic Shock A person goes to the emergency room in the U.S. every 10 seconds over an allergic reaction to food. Could this gadget bring the numbers down?This Already-Approved Drug Could Stop Food Allergies’ Worst Reactions A pair of new papers unlock crucial new insights into what goes on in the body when anaphylaxis occurs, and indicate how an existing asthma medication could one day help prevent these life-threatening allergic reactions
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