A new vaccine might be able to block the toxic effects of the animal tranquilizer xylazine, which is being added to illicit drugs and increasing overdose risk.
“We demonstrated that a vaccine can reverse the symptoms of a xylazine overdose in rodents,” senior researcher Kim Janda, a professor of chemistry at Scripps Research in La Jolla, Calif., said in a news release reporting their findings.laced with xylazine prompted the White House Office of National Drug Control Policy to declare this combination an emerging threat to the United States, researchers noted.Xylazine is thought to work by reducing blood flow to the brain.
The team tested three vaccine formulations in which a xylazine molecule was paired with different protein types, in hopes of prompting an immune response that would create anti-xylazine antibodies.significantly increased movement in mice given xylazine after 10 minutes, while two of the three led to an improvement invaccines
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