An analysis of patients with lung metastases from colorectal cancer showed that definitive surgery and ablative radiation offered similar 5-year overall survival benefits.
In patients with pulmonary oligometastases from colorectal cancer , both stereotactic body radiotherapy and surgery led to similar overall survival rates at 5 years. However, those who received surgery had significantly better progression-free and disease-free survival rates, as well as a longer time to intrathoracic progression.
In the current analysis, researchers compared outcomes among 335 patients with lung metastases from CRC who underwent surgery or SBRT, using data from the Peking University Cancer Hospital and Institute between March 2011 and September 2022. A total of 251 patients were included in the final analysis after propensity score matching, 173 underwent surgery and 78 received SBRT. The median follow-up was 61.6 months in the surgery group and 54.4 months in the SBRT group.At 5 years, rates of freedom from intrathoracic progression were more than twofold higher in the surgery group than in the SBRT group .
Both treatments were well-tolerated with no treatment-related mortality or grade ≥ 3 toxicities. In the surgery group, 14 patients experienced complications, including atrial fibrillation and prolonged air leaks . In the SBRT group, radiation pneumonitis was the most common adverse event .
This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.
Colorectal Cancer (CRC) Surgery Secondary Malignant Neoplasm Of The Lung Secondary Malignant Lung Neoplasm Secondary Lung Cancer Metastatic Lung Cancer Lung Metastases Lung Metastasis Lung Cancer Lung Carcinoma Cancer Of The Lung Metastasis Metastatic Carcinoma Metastatic Cancer Metastases Lung Cancer Malignant Neoplasia Carcinoma Malignant Neoplasm Toxicology
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