SARS-CoV-2 replication persists for weeks in lungs after symptom onset in severe COVID-19 medrxivpreprint UCT_news LSHTM WitsUniversity lung COVID19 coronavirus covid SARSCoV2 symptom symptoms
By Tarun Sai LomteMar 13 2023Reviewed by Benedette Cuffari, M.Sc. *Important notice: medRxiv publishes preliminary scientific reports that are not peer-reviewed and, therefore, should not be regarded as conclusive, guide clinical practice/health-related behavior, or treated as established information.
Postmortem studies have reported persistent virus in tissues by immunohistochemistry or polymerase chain reaction assay. SARS-CoV-2 detected in these analyses may not be replication-competent, which can only be determined by viral culture. Study findings Culturable virus was detected in 38% of patients for up to four weeks after symptom onset. Contrastingly, in a control cohort of ambulatory subjects, culturable virus was detected in one nasopharyngeal swab sample at day 12 post-onset but not in samples collected on day 19. Notably, multiple organs were positive for SARS-CoV-2 by PCR in Delta cohort decedents who were positive for the culturable virus.
Similarly, an attenuated CD4+ and CD8+ T helper type 1 cell response was observed in cells from the deconstructed lung tissues of decedents from the Delta cohort.
United States Latest News, United States Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
Greater Manchester's new Covid hotspots revealedAround one in 14 of the region's hospital beds are currently occupied by patients with coronavirus
Read more »
“People are pruning”: are you experiencing a friendship recession?“I have one uni friend I’m close with and a couple of old friends from my teens, but I’d say my social life is a third of what it once was”
Read more »
Theatre group prepares for triumphant first full production since CovidThe script will see Cotton Shed Theatre cast opening boxes and going on adventures visiting different pantomimes to find missing props for Cinderella
Read more »
Covid mental health toll was 'small', study says - unless you were a womanA major study this week in the British Medical Journal (BMJ) found the mental fallout from the pandemic was 'small'. But for a lot of more vulnerable minority groups, the pandemic was anything but ‘minimal’.
Read more »
Glenn Close forced to miss Oscars after testing positive for Covid-19Glenn Close forced to miss out on presenting at the Oscars after testing positive for Covid-19.
Read more »
Oscars presenter Glenn Close forced to drop out after positive Covid testAccording to reports actress Glenn Close will be sitting out this year's Academy Awards after testing positive for Covid-19 and is currently ''isolating and resting'
Read more »