The genes that underlie devastating neurological disorders offer valuable insights on intelligence, psychiatric disorders and the nature of being human, says 2022 Kavli Prize winner Christopher Walsh. [Sponsored by KavliPrize]
It was 1993, and Walsh, who had just set up his lab at Harvard Medical School, was at a conference in Venice, listening to a pediatric neurologist describe an extended family in which early brain development frequently went awry.
“I wanted to be the first person to run up to him after his talk, because I imagined that everyone else in the audience was thinking the same thing: What a perfect way to study the genetics of the human brain.” Walsh and professors Jean-Louis Mandel, Harry Orr and Huda Zoghbi received the 2022 Kavli Prize in Neuroscience for their work.
How can anatomically diverse brains produce brilliant minds? Individuals with PVNH have blobs of neurons that are clearly in the wrong place. Yet some of these people are CEOs or medical students or computer programmers, and some have IQs of 140. Surprisingly, it looks like they are using those abnormally placed neurons to think. The neurons appear to be wired up to the regular cortex—sometimes in weird ways. It’s just a completely different way of putting the brain together.
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