In a study in mice, an experimental drug targeted the 'stickiness' that can prevent injured brain tissue from functioning as it should, with researchers expecting similar success in humans.
A 3D magnetic resonance imaging scan of the brain of a 65-year-old after a stroke. The orange colour represents dead tissueA drug that improves motor skills and memory in mice after the most common form of stroke may one day fill an unmet need in treatment for this debilitating condition.
Next, the team measured the time it took for the mice to escape a maze that they learned to navigate pre-stroke. The mice that received the drug solved the maze more than twice as quickly, on average, compared with those given saline injections, suggesting the treatment improved their memory. When the team imaged the brains of the mice, they found that those given the peptide had an increased number of connections between their neurons. Brain stem cells had also migrated into the injury site, forming new neurons.
“The system that is influenced by this peptide is also induced in other forms of stroke and in brain haemorrhage, so one might imagine that it will have activity in these other stroke types,” says Carmichael.
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