Restoring the function of a human cell surface protein in yeast cells

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Restoring the function of a human cell surface protein in yeast cells
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Yeast cells are widely used to study G protein-coupled receptors (GPCRs), a large group of cell surface proteins in humans. However, several of these proteins lose their function when introduced into yeast cells. To tackle this issue, researchers developed an innovative strategy to restore GPCR function in yeast cells by inducing random mutations.

Kinesin proteins eat away at microtubules, shortening them and pulling chromosomes to opposite spindle poles during cell division in most organisms. However, fission yeast lacks these proteins, and ...

Researchers report that a yeast cells can actively regulate a process called phase separation in one of their membranes. During phase separation, the membrane remains intact but partitions into ... Researchers have developed a high-throughput screen methodology to identify compounds affect a key G protein coupled receptor rhodopsin . GPCRs mediate many important physiological ...

Academics have genetically modified yeast cells to help scientists control how they react to their environment in a more desirable way. Yeast was chosen because it shares key characteristics with ...

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