A new article analyzes in depth the physical problems associated with DNA packaging that have often been neglected in structural models of chromosomes. The study demonstrates that the multilaminar organization of DNA, proposed from previous experimental research, is fully compatible with the structural and functional properties of chromosomes.
Researchers explain the organization of DNA in chromosomes from repetitive interactions between nucleosomes
The enormously long genomic DNA molecules in eukaryotic organisms must be tightly folded to fit into the micrometric dimensions of the chromosomes compacted during mitosis to protect the genetic information before cell division. Histones proteins were selected early in evolution to transform DNA into chromatin filaments formed by many nucleosomes. The central part of each nucleosome is a cylindrical structure formed by approximately two turns of DNA wrapped around an octamer of histones.
The spontaneous formation of well-defined three-dimensional patterns is in agreement with the contemporary research in nanoscience and nanotechnology that has been obtaining many impressive structures of different sizes, self-assembled from different biological and synthetic repetitive building blocks.
Human Biology Epigenetics Genetics Biochemistry Research Biotechnology Organic Chemistry Engineering And Construction Engineering
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