Today's Video Headlines: 03/24/26
Scientists at three universities have turned to nature to find a property that rivals the benefits of GLP-1 drugs without the What they’ve discovered, in the cold blood of a creature that grows up to 33 feet long, is poised to shake up the competition.
Up to now, GLP-1 medications have had a stranglehold on the pharmaceutical market, with hundreds more in the works. But despite the public relations power of GLP-1-mania, studies showLeslie Leinwand, a distinguished professor of Molecular, Cellular and Developmental Biology at the University of Colorado Boulder, has been studying pythons in her lab for decades,,” senior author Leinwand paid close attention to the volume of food these snakes consume at one time. A single meal satiates them for months, without sacrificing metabolic balance or muscle mass.Scientists discover 'death complex' that could worsen Alzheimer's — and how to fight itLeinwand has found that the hours after they eat are a critical time: Their hearts expand by 25% “and their metabolism speeds up 4,000-fold to help them digest their meal,” according to CU Boulder. Jonathan Long, an associate professor of pathology at Stanford School of Medicine, specializes in the study of metabolites, the substances in the blood that fuel metabolism. The two researchers partnered up to try to unlock the mysteries of the python’s biology. Long, who typically studies mammals, told CU Boulder that “if we truly want to understand metabolism, we need to go beyond looking at mice and people and look at the greatest metabolic extremes nature has to offer.”The team behind this study collected blood samples from two python species, ball and Burmese, immediately following their meals, administered every 28 days.Of the more than 200 metabolites the researchers identified in the blood samples, one stood out for its elasticity: para-tyramine-O-sulfate . That isolated metabolite was sent to Baylor University, where researchers gave a set of obese and lean mice high doses of pTOS. The metabolite noticeably affected the hypothalamus — the part of the brain that controls appetite — and triggered weight loss in the mice. The rise of ‘agonorexia’: GLP-1s feeding dangerous food and body image obsessions, sparking brand new eating disorders Pythons produce pTOS in their guts, and while low levels of the metabolite are also found in human urine, pTOS does not naturally occur in mice. This could help to explain why the compound hasn’t yet been considered for weight loss, since most research for this class of drugs is performed on mice and rats.But the many side effects of the synthesized version found in Wegovy, Ozempic and others have deterred large portions of the drugs’ millions of users from continuing what are meant to be long-term, if not lifelong, medications., a start-up that they hope will someday produce a synthetic version of python metabolites that may be able to replace standard GLP-1s for people especially sensitive to the side effects.“You look at extraordinary animals that can do things that you and I and other mammals can’t do, and you try to harness that for therapeutic interventions.”Right in time for spring: Hypershell drops first-ever discount on X UltraMeet the $26 massage gun families are fighting over — “everyone wanted to use it”'Preliminary findings' revealed in fatal fire that killed beloved NHL reporter, three childrenHow flight attendant likely survived 300-foot ejection from LaGuardia crash: expert Royal family raised concerns over Meghan Markle’s ‘very sexy’ ‘Suits’ role: ‘They’ve never seen anything like that’Starbucks’ Hannah Montana Drink Flavor Fail Sends Fans Into Furious Frenzy: “Did We FORGET In The Show She HATES Raspberry” Stream It Or Skip It: 'Deadloch' Season 2 On Prime Video, Where Two Mismatched Detectives Investigate A Murder In Crocodile Country
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