This article explores the interconnectedness of psoriasis, a chronic inflammatory skin condition, and systemic health issues. It delves into the impact of psoriasis on various comorbidities, highlighting the increased risk of cardiovascular disease, diabetes, inflammatory bowel disease, and depression associated with its severity. The article also discusses treatment guidelines for psoriasis, emphasizing the role of biologics like TNF inhibitors and IL-17 inhibitors in managing both skin symptoms and systemic complications.
Instructor, Department of Dermatology, Harvard Medical School; Associate Physician, Department of Dermatology, Brigham and Women's Hospital, Boston, MassachusettsAssistant Professor, Department of Dermatology, Harvard Medical School; Associate Physician, Department of Dermatology, Brigham and Women's Hospital, Boston, Massachusetts
Disclosure: Megan H. Noe, MD, MPH, MSCE, has disclosed the following relevant financial relationships: Serve as a director, officer, partner, employee, advisor, consultant, or trustee for: Boehringer Ingelheim; Argenx; Takeda that affects approximately 2%-4% of adults in Western countries. Over the past decade, discovery of the pathogenic pathways in psoriasis has led to a greater understanding of the role psoriasis plays in systemic inflammation and associated comorbidities.
increases with disease severity, and patients with moderate to severe psoriasis at greater risk for depression than are patients with mild psoriasis. Therecommends screening for depression in the general adult population.
Given the strong relationship between psoriasis and CVD, the effect of psoriasis treatment on markers of CVD and subsequent CV events has been explored. A retrospectivelooking at claims data of almost 10,000 psoriasis patients showed a statistically significant lower number of CV events in patients on TNF inhibitors compared with patients on< .01).
Psoriasis Comorbidities Inflammation Biologics Depression
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