This year’s American College of Gastroenterology meeting featured encouraging findings for apraglutide, vonoprazan, rifaximin, and biologics in conditions ranging from heartburn to colitis.
Hello. I’m Dr David Johnson, professor of medicine and chief of gastroenterology at Eastern Virginia Medical School in Norfolk, Virginia. In this series, I’ll be giving you my top studies presented at ACG 2024, which will be split into two parts. These studies are not presented in any order of priority because I think they all have clinical applications, some of which are more immediate.
Physical testing showed reduction in grip strength in approximately half of participants, including both right and left grip. More than 70% had at least one abnormal positive provocative test. ICI colitis is graded on a scale. Whereas grade 1 ICI colitis indicates increased stool frequency of less than four a day and the absence of symptoms, grade 2 indicates a progression to a stool frequency of 4 to 6 times a day, the appearance of blood or mucus in the stool, and symptoms like abdominal pain.
There’s a teaching point in the study’s other key finding, which is that following biologic initiation, steroids were more rapidly discontinued with vedolizumab vs infliximab . Therefore, vedolizumab may have the added benefit of patients being able to get off steroids more quickly. That’s the take-home message: Vedolizumab may be better. We certainly are comfortable with both biologics, but patients getting off steroids would be better.and we don’t want to miss it.
Fass R, Chen JW, Heidelbaugh JJ, et al. Heartburn frequency and symptom improvement rates of treated episodes when switching from daily to on-demand vonoprazan treatment for non-erosive reflux disease. Program and abstracts of the American College of Gastroenterology 2024 Annual Scientific Meeting; October 25-30, 2024; Philadelphia, Pennsylvania. Presidential Plenary Session 1, Presentation 4.
IBD - Inflammatory Bowel Disease IBD Overuse Injury Repetitive Strain Injury Cumulative Trauma Disorder Occupational Overuse Syndrome WRULD - Work Related Upper Limb Disorder WRULD Colitis Medical Conferences Professional Societies Cytomegalovirus Colitis Cmv Colitis Diarrhea Diarrhoea Biologic Therapy Biologics Hepatic Encephalopathy
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