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– the average survival after diagnosis is between 12 and 15 months. And just 6.9% of patients survive beyond five years, making it one of the most poorly survived cancers.
Researchers now believe that immunotherapy, which harnesses the immune system to target cancer cells, could be a turning point in the treatment of glioblastoma.Standard treatments for glioblastoma – like surgery, radiation and chemotherapy – are often only temporarily effective. The tumours are highly resistant to these treatments due to the cancer's ability to suppress immune responses and the presence of the blood-brain barrier, which restricts most drugs from reaching the brain.
Despite the promise of immunotherapy, making it effective for glioblastoma remains a challenge. Funding shortages have hampered brain cancer research in the past. ButFor 20 years, I have studied how the immune system can be manipulated and modulated during cancer and chronic infection.
While glioblastoma remains a complex and challenging disease to treat, immunotherapy offers a potential pathway to better outcomes for patients. But to date, there are no approved clinically available immunotherapies to improve the lives of patients with glioblastoma.
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