A telephone-based weight loss program leads to meaningful 1-year weight loss in women with stage II/III breast cancer and obesity.
A telephone-based weight-loss intervention led to clinically significant weight loss in women with stage II/III breast cancer and overweight or obesity, according to a 1-year analysis of a phase 3 study.
Although effective across all demographic and racial/ethnic subgroups, the intervention was more effective in postmenopausal and non-Black/non-Hispanic participants.Obesity is associated with increased risks for recurrence, mortality, comorbidities, and poor quality of life in patients with breast cancer. Prior weight-loss studies were small, included mostly non-Hispanic White patients, and used in-person formats that may not be applicable to a broader population. Researchers conducted a secondary analysis of a phase 3 clinical trial involving 3180 women with stage II/III human epidermal growth factor receptor-negative breast cancer and a BMI ≥ 27 who were randomly assigned 1:1 to receive either a 2-year telephone-based weight-loss intervention plus standard health education materials or health education materials alone . The weight loss intervention promoted weight loss through caloric restriction and increased physical activity .At 1 year, participants in the intervention group achieved a mean weight loss of 4.3 kg, equivalent to 4.7% of baseline body weight, whereas those in the control group gained a mean of 0.9 kg or 1.0% of baseline body weight ; similarly, 22.5% in the intervention group and 5.0% in the control group lost 10% of baseline body weight than among premenopausal women , and less weight loss among Black and Hispanic participants than among participants of other racial and ethnic groups . Participants in the weight loss intervention completed a median of 26 out of 30 planned coaching calls during the first year, and weight loss was positively correlated with the number of calls completed , and Black and Hispanic women participated in fewer calls than those of other racial and ethnic groups (median, 23 and 22 vs 26;These findings “demonstrate the feasibility of implementing a lifestyle based WLI as a part of breast cancer treatment,” the study authors concluded. “While BWEL showed successful weight loss on average, it is not clear if the amount achieved will be sufficient to produce meaningful improvement in prognosis,” Anne McTiernan, MD, PhD, University of Washington, Seattle, wrote in an, further adding that “trials of weight loss treatments that produce greater degrees of weight loss are also needed in patients with breast cancer, both to determine risk-benefit ratios and to provide treatment options for this population.”Over 20% had missing 1-year weight data due to pandemic-related virtual visits, disproportionately among younger, Black, hormone receptor-negative, and lower-income participants. Women in the study were participating in the coaching calls during the collection of weight loss data. Detailed diet and activity data were limited to a subset, precluding full behavioral analyses.The study was supported by grants from the National Cancer Institute of the National Institutes of Health. Additional support was provided to Ligibel by the Susan G. Komen Foundation, Breast Cancer Research Foundation, and American Cancer Society. Several study authors reported receiving grants or personal fees and having other ties with various sources. Additional disclosures are noted in the original article. This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.Comments on Medscape are moderated and should be professional in tone and on topic. You must declare any conflicts of interest related to your comments and responses. Please see our
Malignant Breast Neoplasm Breast Carcinoma Weight Loss Weight Management Obesity Obese Cancer Malignant Neoplasia Carcinoma Malignant Neoplasm Breast Mammary Gland Genomics Genomic Medicine Epidermal Growth Factor Receptor EGFR Epidermal Growth Factor Receptor (EGFR) Grant Receptors
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