Men with localized prostate cancer were randomly assigned to receive either SBRT or control radiotherapy in a phase 3 trial.
Five-fraction stereotactic body radiotherapy was found to be noninferior to conventionally or moderately hypofractionated radiotherapy in treating localized prostate cancer , with a 5-year freedom from biochemical or clinical failure rate of 95.8% vs 94.6%. A downside to SBRT was that it was associated with a higher incidence of late genitourinary toxic effects.Radiotherapy is considered curative for the majority of patients with localized prostate cancer .
In the new study, researchers conducted a phase 3, international, open-label, randomized controlled trial involving 874 men with localized prostate cancer.The primary endpoint was freedom from biochemical or clinical failure, with a critical hazard ratio for noninferiority of 1.45. The trial was conducted across 38 centers in the United Kingdom, Ireland, and Canada, with a median follow-up of 74 months.SBRT was found to be noninferior to conventional radiotherapy, with a 5-year freedom from biochemical or clinical failure rate of 95.8% vs 94.
This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.
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