Dr Bishal Gyawali discusses tips for reading a phase 3 clinical trial publication, focusing on points to review carefully before you start diving into the paper.
Hello, everyone. This is Dr Bishal Gyawali from Queen's University, Kingston, Canada, and I'm happy to be back with you. This is. Today we'll discuss how to read a phase 3 clinical trial publication.
You might be surprised that I'm asking this question of who wrote the paper, because the obvious answer would be, of course, that the authors wrote the paper. As you will see in many new cancer drug trials, the authors actually don't write the paper. I'll give you some examples of that. In many of the new cancer drug trials, you'll see that the funder was involved in the design, collection, analysis, and interpretation of the data, as well as the writing of the manuscript. I have no problem with the funder being involved in designing the trial and collection of the data, but the analysis should be done independently of the funder, who has a big financial stake in the outcomes.
Why am I being so critical about this? When you write a manuscript and you have billions of dollars at stake, then you will try to write the manuscript in a way that will make your drug look much better than what it actually is. This is what we call a spin.
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