A new study found that tirzepatide, the active ingredient in Mounjaro, caused more weight loss than Ozempic's semaglutide. Experts said the study adds to a body of research doctors are increasingly relying on to guide people with obesity and type 2 diabetes.
Maggie O’Neill is a health writer and reporter based in New York who specializes in covering medical research and emerging wellness trends, with a focus on cancer and addiction. Prior to her time at Health, her work appeared in the Observer, Good Housekeeping, CNN, and Vice. She was a fellow of the Association of Health Care Journalists’ 2020 class on Women’s Health Journalism and 2021 class on Cancer Reporting.
, revealed that people on tirzepatide were “significantly more likely to achieve weight loss” than those taking semaglutide., but some doctors prescribed them off-label—or for a different purpose than approved by the FDA, a permissible practice—to help with obesity. More recently, the FDA has approvedTirzepatide and semaglutide work to promote weight management in part by stimulating insulin production in the pancreas and delaying stomach emptying, making people feel fuller for longer.
For the study, Rodriguez and her team analyzed the electronic health records of 18,386 people taking either tirzepatide or semaglutide between May 2022 and September 2023. The mean age of the participants was 52 years old, 70% were female, and the majority—77%—were White. Just over half had type 2 diabetes.
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