Novel vaccine against Lyme disease reported to be safe and effective TheLancetInfDis uzgent vaccine lymedisease vaccination disease
By Dr. Chinta SidharthanJul 11 2023Reviewed by Benedette Cuffari, M.Sc. In a recent study published in The Lancet Infectious Diseases, researchers determine the safety and immunogenicity of a novel candidate vaccine against Lyme borreliosis.
Lyme disease is caused by the pathogenic spirochetes belonging to the Borrelia burgdorferi sensu lato complex. This species comprises B. burgdorferi sensu stricto, which is responsible for serotype 1, B. garinii, which causes serotypes 3, 5, and 6, as well as B. afzelii and B. bavariensis, which cause serotypes 2 and 4, respectively.
The distribution of previous monovalent Lyme borreliosis vaccines was discontinued in the U.S. due to low acceptance after concerns about potential autoimmune arthritis induction following vaccination; however, no evidence was found for this safety concern. The hexavalent VLA15 vaccine contains three lipidated fusion proteins, each of which link the OspA C-terminal domains of two serotypes to ultimately target six serotypes.
The solicited local adverse reactions included pain, erythema, swelling, tenderness, itching, and induration in the injection site. Systemic reactions included fever, nausea, headache, fatigue, rash, arthralgia, flu-like symptoms, and myalgia for one week after administration of the vaccine.
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