Randomized trial data showed no difference in ischemic events or major bleeding with prolonged vs no anticoagulation.
showed that at 1 year, there is no difference between continued anticoagulation and no anticoagulation for either ischemic or bleeding outcomes.
"Real-world studies gave us some suggestion that it is used frequently and may be associated with improved outcomes," she continued, adding that previously,"no randomized trial had investigated the effects of stopping or prolonging postprocedural anticoagulation in this kind of population." Yan reported that all the 2989 patients who participated in the trial had initially been treated with bivalirudin during and up to 4 hours after their procedures. The patients were then randomly allocated to either a"prolonged anticoagulation" group or a"no anticoagulation" placebo group .
Exploratory findings suggested that at both 30 days and 1 year, there might be a difference in MACE according to the anticoagulant regimen used. Of the 1494 patients in the prolonged anticoagulation group, 474 had been given enoxaparin, 510 UFH, and 510 bivalirudin. The cumulative incidence of MACE at 1 year was 47% lower with enoxaparin than with no anticoagulant use. There were no apparent differences, however, for UFH (HR=1.
"If you have a successful PCI — so you have resolved the thrombosis, and you have implanted your stent well, maybe with intravascular imaging — then you are safe enough that you do not need an additional anticoagulation burden," Gragnano said ahead of Yan's presentation.
Anticoagulation Therapy Anticoagulant Anticoagulation Thromboembolism Primary And Secondary Prevention Of Coronary Arter Primary And Secondary Prevention Of Coronary Hear Primary And Secondary Prevention Of Atherosclerot
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