Study: Pfizer COVID pill showed no benefit in younger adults nejm
However, data regarding the effectiveness of nirmatrelvir against the omicron variant and in patients with previous immunity against SARS-CoV-2 are limited. Therefore, our objective was to assess the effectiveness of nirmatrelvir in preventing severe Covid-19 outcomes during the omicron surge in a population with widespread SARS-CoV-2 immunity.
Most of the patients who were tested for Covid-19 during the study period underwent such testing because of the occurrence of symptoms. Polymerase-chain-reaction and state-regulated antigen tests were freely available at the request of the patient. However, no screening for SARS-CoV-2 was performed, even when a patient had been exposed to a person with confirmed Covid-19.
The study was approved by the Community Helsinki and Data Utilization committees of CHS. The study was exempt from the requirement to obtain informed consent owing to the retrospective design.We evaluated integrated patient-level data that were maintained by CHS from two primary sources: the primary care operational database and the Covid-19 database.
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