A Correspondence article published in the Journal of Hematology & Oncology reports the detection of SARS-CoV-2 spike protein in blood clots retrieved from COVID-19 patients with acute ischemic stroke and myocardial infarction.
]. We aimed to investigate whether isolated SP can be present in clots retrieved by endovascular treatment in COVID-19 patients with AIS and AMI.
The study was conducted on patients admitted to the Emergency Department of Policlinico Umberto I Hospital, University of Rome La Sapienza, from March 2020 to April 2021. Among a series of consecutive adult patients with large vessel occlusion -related AIS or with AMI and a concomitant diagnosis of COVID-19, we retrospectively selected patients with thrombus available for histological analysis.
SARS-CoV-2 RNA extraction from clots was carried out by using Total RNA Purification Kit , according to the manufacturer’s instructions. Viral RNA was amplified for the qualitative detection of SARS-CoV-2 RNA using a real-time RT-PCR system , as previously described [We enrolled four COVID-19-positive patients: three with LVO AIS and one affected by AMI . All COVID-19 patients had lung ground-glass opacity on pulmonary CT scan.
The relative amount of platelets and fibrin/red blood cells did not significantly differ from COVID-19 thrombi and controls. COVID-19 thrombi retrieved from cerebral arteries showed mild positivity for SP, whereas SP immunostaining was more marked in the COVID-19 thrombus retrieved from anterior descending coronary artery (Fig.
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