Human antibody responses to SARS-CoV-2 infection after two years Antibody SARSCoV2 Coronavirus Disease COVID Respiratory Infection Medicalrisk AntibodyResponse Indonesia PLOSONE
By Dr. Priyom Bose, Ph.D.Aug 21 2022Reviewed by Benedette Cuffari, M.Sc. The coronavirus disease 2019 , which is caused by infection with the highly infectious severe acute respiratory syndrome coronavirus 2 , has been diagnosed in almost 600 million people worldwide and caused almost 6.5 million deaths. Although the role of the humoral immune response against SARS-CoV-2 infection is well understood, the duration of protection post-infection has yet to be determined.
This finding indicates the possibility of immune protection for a longer period. In fact, SARS-CoV-2-specific immunoglobulin G levels have been reported to persist for six to eight months, after which they wane off. There remains a need to develop an appropriate disease prevention model for the general population. This would require a suitable surveillance system that can accommodate data from hundreds of respondents.
Related StoriesThe current study includes one prospective cohort study and a case-control study. To determine the anti-SARS-CoV-2 antibody kinetics for two years, with respect to disease severity, the scientists adapted a prospective observational method. Study findings Participants for the case study were recruited from the Academic Hospital of the Universitas Gadjah Mada in Yogyakarta. For each confirmed COVID-19 case, three uninfected control candidates who lived within a one-kilometer radius from the infected person’s residence were recruited, which amounted to a total of 165 COVID-19 patients and 495 healthy control individuals.
Conclusions It is important to investigate anti-SARS-CoV-2 antibody levels in a given population, as this metric could provide insights into past and present infections. Additionally, this data will help examine the antibody-mediated protective immunity and immunopathology of COVID-19.
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