Several promising therapies targeting fundamental skin aging processes are undergoing clinical trials, offering hope for a regulatory-approved anti-aging indication. These therapies aim to address various intrinsic and extrinsic drivers of skin aging, including inflammation, DNA damage, and mitochondrial dysfunction. Studies highlight the role of inflammation in perpetuating skin cell senescence and the SASP phenotype, which accelerates aging. Researchers are exploring targeted interventions like senolytics and topical estrogens to prevent or reverse these age-related changes. The field is advancing with a deeper understanding of aging mechanisms, paving the way for more personalized and effective anti-aging treatments.
NEW YORK — Targeted at fundamental processes that control skin aging, several therapies are currently being tested for the promise of a regulatory-granted antiaging indication, according to an update on a potentially huge area of dermatology practice.
Molecular studies of aging skin produce evidence of damaged DNA proteins, mitochondrial dysfunction, oxidative stress, downregulated collagen, and other processes that together and independently drive the adverse changes most closely associated with an aging appearance, He added. However, the variability in the aging process can also be seen within skin types. Part of the effort to isolate molecular targets in preventing skin aging has been based on studies comparing gene expression of women with a skin appearance that is younger than their chronological age, according to He. These studies have generated insight into which processes independently drive skin aging.that evaluated gene expression among women from ages 20 to 74 years.
with topical rapamycin, an improvement in skin appearance, including a reduction in wrinkles, was accompanied by a significant increase , a topical estrogen analog, has shown promise for restoring collagen and improving the appearance of skin in postmenopausal women. Broken down in the systemic circulation if absorbed, MAP targets the beta-estrogen receptor, which is expressed in the skin but not the reproductive tract, which might be relevant to the safety of this drug, He reported.
Abigail K. Langton, PhD, senior lecturer at the Centre for Dermatology Research, The University of Manchester, Manchester, England, was the senior author of a 2023in which a near doubling of worldwide expenditures for modifying aging skin was predicted by 2030 and was asked to comment on this research.
“Topical treatments remain the preferred choice for skin rejuvenation as they act directly on the skin to address signs of aging effectively, offering precision and safety with minimal risk,” Langton said.
SKIN AGING THERAPIES INFLAMMATION SENOLYTICS TOPICAL ESTROGENS
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