Science, Space and Technology News 2024
Recent research has highlighted the significant role of dopamine in neural development and its link to autism spectrum disorder . Leading investigators from Nantong University discovered correlations between disrupted dopaminergic signaling and neural development abnormalities in both human and zebrafish models. These findings open new avenues for understanding autism’s etiology and developing targeted therapeutic interventions.
To analyze the developmental deficits in ASD systematically, two large publicly available data sets were retrieved from the National Center for Biotechnology Information Gene Expression Omnibus database and RNA sequencing data from Arkinglab. Transcriptome analysis of human brains revealed significant correlations between changes in dopaminergic signaling pathways and neural developmental signaling in patients with autism.
Dr. Chen comments, “We were surprised by the extent of the impact that dopaminergic signaling has on neuronal specification in zebrafish, potentially laying the groundwork for circuit disruption in autism-related phenotype. Furthermore, the unexpected involvement of integrins as downstream targets of dopaminergic signaling provides new insights into the mechanisms underlying neurodevelopmental disorders.
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