Study used a Mendelian randomization approach to identify REG1A and REG1B as potential biomarkers for early detection of pancreatic cancer, showing their causal effects and significance in cancer screening.
By Dr. Chinta SidharthanMay 19 2024Reviewed by Susha Cheriyedath, M.Sc. In a recent study published in the journal Cell Genomics , a team of researchers in China conducted a case-control study to analyze a large panel of serum proteins to identify protein biomarkers for incident pancreatic cancer . They used a Mendelian randomization approach to assess the potential causal effects of these proteins in pancreatic cancer .
Traditional cancer biomarkers, which include the carcinoembryonic antigen and carbohydrate antigens 19-9, 125, and 242, have shown varying specificity for pancreatic cancer. Inflammatory proteins such as tumor necrosis factor , C-reactive protein , and interleukin-6 have also not shown significant associations with incident pancreatic cancer.
Circulating proteins were measured from fasting serum samples using a technique based on proximity extension assay. Close to 1,500 proteins were measured and quantified using a Normalized Protein eXpression or NPX value. Various baseline characteristics such as smoking status, alcohol consumption levels, education levels, glycemic indices, and body mass index were compared between the pancreatic cancer cases and matched healthy controls to identify categorical variables.
Related StoriesData from a large-scale quantitative trait locus study of proteins and various genome-wide association studies of pancreatic cancer among European populations was used for the Mendelian randomization analysis.
Pancreatic Cancer Protein Antigen Blood Carbohydrate Cell Diabetes Genome Genomics Locus Mortality Necrosis Pancreas Protein Expression Proteomics Tumor Tumor Necrosis Factor
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