Science, Space and Technology News 2024
Research from Umeå University shows that type 2 diabetes impedes the elimination of Alzheimer’s-related proteins, suggesting a higher cognitive risk, highlighting the importance of diabetes management.-related proteins, suggesting potential strategies to mitigate cognitive risks by managing blood sugar levels.
Immediately after the infusion of the sugar solution, the groups had similar values. Soon, the values of beta-amyloids fell sharply in the control group, while the values of the amyloid-degrading enzyme rose. Among the group with type 2 diabetes, there were no changes, i.e. the levels of beta-amyloid did not decrease, nor did there be an increase in the enzyme that breaks down amyloid.
The study was conducted on ten people with type 2 diabetes and eleven people without diabetes in the control group. The participants were aged 66–72 years. The researchers measured the concentrations in the blood of the beta-amyloids Aβ1-40 and Aβ1-42 as well as of an enzyme that breaks down the beta-amyloids in a test group with type 2 diabetes and in a healthy control group. The two groups were given infusion of glucose for four hours, which induced acute hyperglycemia, i.e. high blood sugar levels, after which repeated samples were taken from the subjects.Immediately after the infusion of the sugar solution, the groups had similar values.
People with type 2 diabetes are at increased risk of Alzheimer’s disease and other cognitive problems. A new study led by Umeå University, Sweden, shows that the reason may be that people with type 2 diabetes have more difficulty getting rid of a protein that may cause the disease.
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