New DELIVER guidelines aim to accelerate nanomedicine development

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New DELIVER guidelines aim to accelerate nanomedicine development
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They're tiny drug-delivery systems 1000 times smaller than a human hair, but while nanomedicines have long been hailed as the future for treating debilitating and life-threatening diseases, their journey from lab to patient has many challenges.

University of South AustraliaSep 6 2024 They're tiny drug-delivery systems 1000 times smaller than a human hair, but while nanomedicines have long been hailed as the future for treating debilitating and life-threatening diseases, their journey from lab to patient has many challenges.

Published in Nature Nanotechnology today, and led by the University of South Australia's Dr. Paul Joyce and the University of Groningen's Prof Hélder Santos, the DELIVER guidelines present early-stage recommendations for nanomedicine development during design, experiment, manufacturing, preclinical, clinical, regulatory, and business phases, so as to maximise the chance of clinical translation.

We only need to think of the recent COVID-19 pandemic to realise the acute value of nanomedicines: more than two thirds of the global population received an mRNA vaccine to immunise against coronavirus, which was made possible by lipid nanoparticles. Our research steps out the core principles that must be met to ensure nanomedicines can successfully overcome translational hurdles, helping researchers, clinicians, and regulatory bodies better manoeuvre through key steps and processes to avoid delays and enable faster clinical delivery.

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