Artificial intelligence platform has the ability to efficiently design T-cell-based vaccines that offer broad protection. The platform could also be used to develop seasonal flu and other vaccines. Researchers from Penn State have teamed up with Evaxion Biotech on a groundbreaking study that reveal
Researchers have developed an AI-generated T-cell-based vaccine that demonstrates effectiveness against COVID-19 in mice, potentially offering long-lasting immunity against emerging variants. This approach, using the RAVEN platform, could also be used for developing improved vaccines for other seasonal viral diseases, such as influenza.
Why do we need a T-cell-based COVID-19 vaccine when the mRNA vaccines that are already in use are so effective? “This means that vaccine manufacturers will have to keep creating new vaccines that target new variants, and people have to keep getting these new vaccines,” he said. If T cells are so great at remembering foreign agents, why were the first-generation COVID-19 vaccines designed to elicit responses from antibodies?
“RAVEN is really adaptable,” Sørensen said. “We don’t have to wait for a new strain of a virus to arrive to develop a vaccine. Instead, we can predict what will be needed in advance. That’s not something that others are doing right now.” “Oftentimes, the influenza vaccines that are designed work only 30-40% of the time, so a lot of people end up getting sick,” he said. “As the world becomes increasingly integrated, that problem will become larger and larger. Our platform uses AI to better predict what will be needed.”
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