Emerging formulations are intended to facilitate the use of adrenaline and reduce delays in administration.
PARIS — While anaphylaxis requires immediate adrenaline administration through autoinjection, the use of this treatment is not optimal. Therefore, the development of new adrenaline formulations aims to facilitate the drug's use and reduce persistent delays in administration by patients and caregivers. An overview of the research was presented at the 19th French-speaking Congress of Allergology.
"These factors contribute to underuse of adrenaline by patients and caregivers," said Neukirch, which results in delays in necessary administration.published in 2023 based on pharmacovigilance data from 30 regional French centers from 1984 to 2022 included 42 reported cases of reactions to AAI, which probably is an underestimate. About 40% of AAI uses occurred during anaphylaxis. The remaining 60% were triggered outside of reactions.
Moreover, needle size is not the most important factor. Rather, it is the strength and speed of injection, which can vary depending on the AAI. Intranasal absorption of dry powder adrenaline appears to be faster than that of EpiPen, thus offering a clinical advantage in the short therapeutic window for anaphylaxis treatment.
Anaphylactic Shock Peanut Allergy Peanut Anaphylaxis Allergy To Peanuts Pharmacokinetics Otolaryngology ENT Specialty Head And Neck Surgery ENT Speciality Pharmacodynamics Allergic Rhinitis Blood Obesity Obese Heart Allergens Plasma Seasonal Allergic Rhinitis Hay Fever Adverse Effects Side Effects Asthma Asthmatic Body Mass Index BMI Caregiver Children Child Childhood
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