Neuroinflammation After COVID-19 With Persistent Depressive and Cognitive Symptoms

Study confirms ongoing braininflammation associated with long COVID JAMAPsych

was measured in the dorsal putamen, ventral striatum, prefrontal cortex, anterior cingulate cortex, and hippocampus. Symptoms were measured with neuropsychological and psychological tests, prioritizing outcomes related to striatal function.across the regions of interest was greater in persons with COVID-DC compared with healthy control participants : mean difference, 1.51 ; 95% CI, 0.04-2.98; 1.51 divided by 9.20 . The difference was most prominent in the ventral striatum and dorsal putamen .

Motor speed on the finger-tapping test negatively correlated with dorsal putamen TSPO V, and the 10 persons with the slowest speed among those with COVID-DC had higher dorsal putamen TSPO Vwas higher in patients with COVID-DC. Greater TSPO Vis evidence for an inflammatory change of elevated gliosis in the brain of an individual with COVID-DC.

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