⚡️Our April issue is out!⚡️With two papers from the TRACERx LungCancer study, clinical trials in Diabetes and ProstateCancer, studies on salt substitution for lowering BloodPressure and on AI for BrainCancer diagnosis, news, opinions, and much more!
Lung adenocarcinomas encompass a broad spectrum of histological appearances. We use multi-region, prospective and longitudinal sampling from the TRACERx dataset to show the relationship between LUAD morphologies and their underlying evolutionary genomic landscape, as well as clinical risk and the nature of metastatic dissemination.
Data from circulating tumor DNA testing were generated for over 1,900 samples across at least 3 time points in a phase 3 clinical trial and used to build a machine learning model to predict patient survival. The model accurately identified patients with a high risk of disease recurrence and could provide a basis for assigning therapies in phase 1/2 clinical trials.
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